| Name | Seasons | No. of episodes | Portrayer | Character summary |
|---|
| Nels Oleson | 1–9 | 147 | Richard Bull | Mercantile proprietor; husband and father |
| Harriet Oleson | 1–9 | 153 | Katherine MacGregor | Mercantile proprietor; wife and mother |
| Nellie Oleson | 1–7, 9 | 104 | Alison Arngrim | Oldest child of Nels and Harriet |
| Willie Oleson | 1–9 | 140 | Jonathan Gilbert | Son of Nels and Harriet |
| Nancy Oleson | 8–9 | 33 | Allison Balson | Daughter of Nels and Harriet, adopted from orphanage |
| Percival Dalton/Isaac Cohen | 6–7 | 11 | Steve Tracy | Nellie’s husband |
| Rachel Brown Oleson | 9 | 2 | Sherri Stoner | Willie’s wife |
| Dr.
Hiram Baker | 1–9 | 113 | Kevin Hagen | Town physician |
| Reverend Robert Alden | 1–9 | 76 | Dabbs Greer | Church minister |
| Melinda Foster | 1–9 | 61 | Ruth Foster | Post office manager |
| Isaiah Edwards | 1–3, 6, 8–9 | 52 | Victor French | Charles’s best friend |
| Grace Snider Edwards | 1–3, 6, 8 | 23 | Bonnie Bartlett / Corinne Camac
|